International Laboratory "Hybrid Nanostructures for Biomedicine"

The development of new MRI-contrast nanostructured composites demonstrating effective generation of reactive oxygen species under the influence of electromagnetic radiation and focused ultrasound for minimally invasive therapy of glioblastoma with in situ MRI control includes:

1. 1) Development of MRI-contrast nanostructured composites based on magnetic nanoparticles and photosensitizers for reactive oxygen species generation.

2. 2) Identification of patterns in the emergence of local sources of photoexcitation under the influence of ultrasound of a specified frequency and intensity, and assessing their effectiveness for activating photosensitizers for reactive oxygen species generation.

3. 3) Establishing the dependence of MRI contrast on the architecture of nanostructured composites.

4. 4) Demonstrating the functionality of the composites invitro, exvivo, and in vivo.

5. 

The development of new MRI-contrast nanostructured composites demonstrating effective generation of reactive oxygen species under the influence of electromagnetic radiation and focused ultrasound for minimally invasive therapy of glioblastoma with in situ MRI control includes:

1. Development of MRI-contrast nanostructured composites based on magnetic nanoparticles and photosensitizers for reactive oxygen species generation.

2. Identification of patterns in the emergence of local sources of photoexcitation under the influence of ultrasound of a specified frequency and intensity, and assessing their effectiveness for activating photosensitizers for reactive oxygen species generation.

3. Establishing the dependence of MRI contrast on the architecture of nanostructured composites.

4. Demonstrating the functionality of the composites in vitro, ex vivo, and in vivo.